ncRNA

SINEUP long non-coding RNA acts via PTBP1 and HNRNPK to promote translational initiation assemblies

***Nucleic Acids Research 48, 20 (2020) PMID: 33130894***

Synthetic in vitro transcribed lncRNAs (SINEUPs) with chemical modifications enhance target mRNA translation

***FEBS Letter, Online ahead of print (2020) PMID: 33012004***

Functional annotation of human long noncoding RNAs via molecular phenotyping

***Genome Res. 30:1377-1 (2020) PMID: 32718982***

An NMR-based approach reveals the core structure of the functional domain of SINEUP lncRNAs

***Nucleic Acids Research: gkaa598(2020) PMID:32697302***

ノンコーディング RNA とクロマチンの相互作用を網羅的に検出する系の開発

RADICL-seq法を用いたncRNAとクロマチンの相互作用やその機能の解析

翻訳を促進するアンチセンスRNA"SINEUPs"の作用機序の解明から生体内応用へ

新たなncRNAのメカニズムを解明し、医療への応用を目指す

RADICL-seq identifies general and cell type-specific principles of genome-wide RNA-chromatin interactions

***Nat Commun 11(1):1018 (2020) PMID: 32094342***

Single-cell transcriptomics reveals expansion of cytotoxic CD4 T cells in supercentenarians

***PNAS 116 (48), 24242-24251 (2019) PMID: 31719197***

Cell Based Assays of SINEUP Non-coding RNAｓThat Can Specifically Enhance mRNA Translation

***J Vis Exp. 144 (2019) PMID: 30774120***

An atlas of human long non-coding RNAs with accurate 5' ends

***Nature 543, 199-204 (2017) PMID: 28241135***