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横浜市立大学大学院生命医科学研究科生命医科学専攻分子細胞医科学研究室ホームページ:研究業績 古久保


  

研究業績

教授: 古久保 哲朗 (Tetsuro Kokubo)

東京大学大学院農学系研究科博士課程修了 (1990年)。
米国NIH研究員(1990-1995年)、奈良先端科学技術
大学院大学助教授(1995-2001年)を 経て現職。

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K. Kasahara, R. Nakayama, Y. Shiwa, Y. Kanesaki, T. Ishige, H. Yoshikawa, T. Kokubo
Fpr1, a primary target of rapamycin, functions as a transcription factor for ribosomal protein genes cooperatively with Hmo1 in Saccharomyces cerevisiae
PLoS Genet, vol.16, No.6, e1008865 (2020)

R. Iwami, N. Takai, T. Kokubo
The function of Spt3, a subunit of the SAGA complex, in PGK1 transcription was restored only partially when reintroduced by plasmid into taf1 spt3 double mutant yeast strains
Genes & Genetic Systems, vol.95, No.3, 151-163 (2020)

Y. Wei, D. Resetca, Z. Li, I. Johansson-Åkhe, A. Ahlner, S. Helander, A. Wallenhammar,V. Morad, B. Raught, B. Wallner, T. Kokubo, Y. Tong, L. Z. Penn, M. Sunnerhagen
Multiple direct interactions of TBP with the MYC oncoprotein
Nat Struct Mol Biol., vol.26, No.11, 1035-1043 (2019)


K. Kasahara, S. Takahata, T. Kokubo
Transcriptional activation is weakened when Taf1p N-terminal domain 1 is substituted with its Drosophila counterpart in yeast TFIID
Genes & Genetic Systems, vol.94, No.1, 51-59 (2019)

K. Watanabe, T. Kokubo
SAGA mediates transcription from the TATA-like element independently of Taf1p/TFIID but dependent on core promoter structures in Saccharomyces cerevisiae
PLOS ONE, vol.12, No.11, e0188435 (2017)

K. Kasahara, A. Higashino, S. Unzai, H. Yoshikawa, T. Kokubo
Oligomerization of Hmo1 mediated by box A is essential for DNA binding in vitro and in vivo
Genes to Cells, vol.21, No.12, 1333-1352 (2016)

K. Watanabe, M. Yabe, K. Kasahara, T. Kokubo
A random screen using a novel reporter assay system reveals a set of sequences that are preferred as the TATA or TATA-like elements in the CYC1 promoter of Saccharomyces cerevisiae
PLOS ONE, vol.10, No.6, e0129357 (2015)

K. Maeshima, K. Kaizu, S. Tamura, T. Nozaki, T. Kokubo, K. Takahashi
The physical size of transcription factors is key to transcriptional regulation in chromatin domains
Journal of Physics: Condensed Matter, vol.27, No.6, 064116 (2015)
*Related article: http://iopscience.iop.org/0953-8984/labtalk-article/60526

A. Higashino, Y. Shiwa, H. Yoshikawa, T. Kokubo, K. Kasahara
Both HMG boxes in Hmo1 are essential for DNA binding in vitro and in vivo
Bioscience, Biotechnology, and Biochemistry, vol.79, No.3, 384-393 (2015)

M. Anandapadamanaban, C. Andresen, S. Helander, Y. Ohyama, M. I. Siponen, P. Lundström, T. Kokubo, M. Ikura, M. Moche, M. Sunnerhagen
High-resolution structure of TBP with TAF1 reveals anchoring patterns in transcriptional regulation
Nat Struct Mol Biol., vol.20, No.8, 1008-1014 (2013)

K. Kasahara, Y. Ohyama, T. Kokubo
Hmo1 directs pre-initiation complex assembly to an appropriate site on its target gene promoters by masking a nucleosome-free region
Nucleic Acids Res., vol.39, No.10, 4136-4150 (2011)

F. Sugihara, K. Kasahara, T. Kokubo
Highly redundant function of multiple AT-rich sequences as core promoter elements in the TATA-less RPS5 promoter of Saccharomyces cerevisiae
Nucleic Acids Res., vol.39, No.1, 59-75 (2011)

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Y. Ohyama, K. Kasahara, T. Kokubo
Saccharomyces cerevisiae Ssd1p promotes CLN2 expression by binding to the 5’-untranslated region of CLN2 mRNA
Genes to Cells, vol.15, No.12, 1169-1188 (2010)

K. Ohtsuki, K. Kasahara, K. Shirahige, T. Kokubo
Genome-wide localization analysis of a complete set of Tafs reveals a specific effect of the taf1 mutation on Taf2 occupancy and provides indirect evidence for different TFIID conformations at different promoters
Nucleic Acids Res., vol.38, No.6, 1805-1820 (2010)

A. Yamazaki, S. Ki, T. Kokubo, M. Yamaguchi
Structure-function correlation of micro1 for micromere specification in sea urchin embryos
Mechanisms of Development, vol.126, No.8-9, 611-623 (2009)

H. Takahashi, K. Kasahara, T. Kokubo
Saccharomyces cerevisiae Med9 is comprised of two functionally distinct domains that play different roles in transcriptional regulation
Genes to Cells, vol.14, No.1, 53-67 (2009)

Y. Tateishi, M. Ariyoshi, R. Igarashi, H. Hara, K. Mizuguchi, A. Seto, A. Nakai, T. Kokubo, H. Tochio, M. Shirakawa
Molecular basis for SUMOylation-dependent regulation of DNA binding activity of heat shock factor 2
J. Biol. Chem., vol.284, No.4, 2435-2447 (2009)


K. Kasahara, S. Ki, K. Aoyama, H. Takahashi, T. Kokubo
Saccharomyces cerevisiae HMO1 interacts with TFIID and participates in start site selection by RNA polymerase II
Nucleic Acids Res., vol.36, No.4, 1343-1357 (2008)

K. Kasahara, K. Ohtsuki, S. Ki, K. Aoyama, H. Takahashi, T. Kobayashi, K. Shirahige, T. Kokubo
Assembly of regulatory factors on rRNA and ribosomal protein genes in Saccharomyces cerevisiae
Mol. Cell. Biol., vol.27, No.19, 6686-6705 (2007)

A. Kobayashi, Y. Watanabe, K. Akasaka, T. Kokubo
Real-time monitoring of functional interactions between upstream and core promoter sequences in living cells of sea urchin embryos
Nucleic Acids Res., vol.35, No.14, 4882-4894 (2007)

T. K. Mal, S. Takahata, S. Ki, L. Zheng, T. Kokubo, M. Ikura
Functional silencing of TATA binding protein by a covalent linkage of the amino-terminal domain of TBP-associated factor 1
J. Biol. Chem., vol.282, No.30, 22228-22238 (2007)

S. Ki, F. Sugihara, K. Kasahara, H. Tochio, M. Shirakawa, T. Kokubo
Magnetic resonance-based visualization of gene expression in mammalian cells using a bacterial polyphosphate kinase reporter gene
BioTechniques, vol.42, No.2, 209-215 (2007)

S. Ki, F. Sugihara, K. Kasahara, H. Tochio, A. Okada-Marubayashi, S. Tomita, M. Morita, M. Ikeguchi, M. Shirakawa, T. Kokubo
A novel magnetic resonance-based method to measure gene expression in living cells
Nucleic Acids Res., vol.34, No.6, e51 (2006)

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T.K. Mal, D. Liu, Y. Masutomi, L. Zheng, Y. Nakatani, T. Kokubo, M. Ikura
Resonance assignments of 30 kDa complexes of TFIID subunit TAF1 with TATA-binding protein
J. Biomol. NMR, vol.33, No.1, 76 (2005)

K. Kasahara, M. Kawaichi, T. Kokubo
In vivo synthesis of Taf1p lacking the TAF N-terminal domain using alternative transcription or translation initiation sites
Genes to Cells, vol.9, No.8, 709-721 (2004)

T. K. Mal, Y. Masutomi, L. Zheng, Y. Nakata, H. Ohta, Y. Nakatani, T. Kokubo, M. Ikura
Structural and functional characterization on the interaction of yeast TFIID subunit TAF1 with TATA binding protein
J. Mol. Biol., vol.339, No.4, 681-693 (2004)

S. Takahata, K. Kasahara, M. Kawaichi, T. Kokubo
Autonomous function of the amino-terminal inhibitory domain of TAF1 in transcriptional regulation
Mol. Cell. Biol., vol.24, No.8, 3089-3099 (2004)

A. Kobayashi, T. Kokubo, Y. Ota, S. Yokoyama
Promoter-specific function of the TATA element in undifferentiated P19 cells
Biochem. Biophys. Res. Commun., vol.310, No.2, 458-463 (2003)

S. Takahata, H. Ryu, K. Ohtsuki, K. Kasahara, M. Kawaichi, T. Kokubo
Identification of a novel TATA element-binding protein binding region at the N terminus of the Saccharomyces cerevisiae TAF1 protein
J. Biol. Chem., vol.278, No.46, 45888-45902 (2003)

A. Kobayashi, T. Miyake, M. Kawaichi, T. Kokubo
Mutations in the histone fold domain of the TAF12 gene show synthetic lethality with the TAF1 gene lacking the TAF N-terminal domain (TAND) by different mechanisms from those in the SPT15 gene encoding the TATA binding protein (TBP)
Nucleic Acids Res., vol.31, No.4, 1261-1274 (2003)

H. Ohdate, C. R. Lim, T. Kokubo, K-i. Matsubara, Y. Kimata, K. Kohno
Impairment of the DNA-binding activity of the TATA-binding protein (TBP) renders the transcriptional function of Rvb2p/Tih2p, the yeast RuvB-like protein, essential for cell growth
J. Biol. Chem., vol.278, No.17, 14647-14656 (2003)

A. Kobayashi, K. Akasaka, M. Kawaichi, T. Kokubo
Functional interaction between TATA and upstream CACGTG elements regulates the temporally specific expression of Otx mRNAs during early embryogenesis of the sea urchin, Hemicentrotus pulcherrimus
Nucleic Acids Res., vol.30, No.14, 3034-3044 (2002)

Y. Tsukihashi, M. Kawaichi, T. Kokubo
Requirement for yeast TAF145 function in transcriptional activation of the RPS5 promoter that depends on both core promoter structure and upstream activating sequences
J. Biol. Chem., vol.276, No.28, 25715-25726 (2001)

A. Kobayashi, T. Miyake, Y. Ohyama, M. Kawaichi, T. Kokubo
Mutations in the TATA binding protein, affecting transcriptional activation, show synthetic lethality with the TAF145 gene lacking the TAF N-terminal domain in Saccharomyces cerevisiae.
J. Biol. Chem., vol.276, No.1, 395-405 (2001)

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Y. Tsukihashi, T. Miyake, M. Kawaichi, T. Kokubo
Impaired core promoter recognition caused by novel yeast TAF145 mutations can be restored by creating a canonical TATA element within the promoter region of the TUB2 gene
Mol. Cell. Biol., vol.20, No.7, 2385-2399 (2000)

T. Kotani, K-i. Banno, M. Ikura, A. G. Hinnebusch, Y. Nakatani, M. Kawaichi, T. Kokubo
A role of transcriptional activators as anti-repressors for the auto-inhibitory activity of TATA box binding of TFIID
Proc. Natl. Acad. Sci. USA, vol.97, No.13, 7178-7183 (2000)

C. R. Lim, Y. Kimata, H. Ohdate, T. Kokubo, N. Kikuchi, T. Horigome, K. Kohno
The Saccharomyces cerevisiae RuvB-like protein, tih2p, is required for cell cycle progression and RNA polymerase II-directed transcription
J. Biol. Chem., vol.275, No.29, 22409-22417 (2000)

T. Kotani, T. Miyake, Y. Tsukihashi, A. G. Hinnebusch, Y. Nakatani, M. Kawaichi, T. Kokubo
Identification of highly conserved amino-terminal segments of dTAFII230 and yTAFII145 that are functionally interchangeable for inhibiting TBP:DNA interactions in vitro and in promoting yeast cell growth in vivo
J. Biol. Chem., vol.273, No.48, 32254-32264 (1998)

D. Liu, R. Ishima, K. I. Tong, S. Bagby, T. Kokubo, D. R. Muhandiram, L. E. Kay, Y. Nakatani, M. Ikura
Solution structure of a TBP-TAFII230 complex: Protein mimicry of the minor groove surface of the TATA box unwound by TBP
Cell, vol.94, No.5, 573-583 (1998)

C. M. Drysdale, B. M. Jackson, R. McVeigh, E. R. Klebanow, Y. Bai, T. Kokubo, M. J. Swanson, Y. Nakatani, P. A. Weil, A. G. Hinnebusch
The Gcn4p activation domain interacts specifically in vitro with RNA polymerase II holoenzyme, TFIID, and the Adap-Gcn5p coactivator complex
Mol. Cell. Biol., vol.18, No.3, 1711-1724 (1998)

T. Kokubo, M. J. Swanson, J-i. Nishikawa, A. G. Hinnebusch, Y. Nakatani
The yeast TAF145 inhibitory domain and TFIIA competitively bind to TATA-binding protein
Mol. Cell. Biol., vol.18, No.2, 1003-1012 (1998)

J-i. Nishikawa, T. Kokubo, M. Horikoshi, R. G. Roeder, Y. Nakatani
Drosophila TAFII230 and the transcriptional activator VP16 competitively bind to the TATA box-binding domain of TATA box-binding protein
Proc. Natl. Acad. Sci. USA, vol.94, No.1, 85-90 (1997)

C. A. Mizzen, X-J. Yang, T. Kokubo, J. E. Brownell, A. J. Bannister, T. O-Hughes, J. Workman, S. L. Berger, T. Kouzarides, Y. Nakatani, C. D. Allis
The TAFII250 subunit of TFIID has histone acetyltransferase activity
Cell, vol. 87, No.7, 1261-1270 (1996)

X. Xie, T. Kokubo, S. L. Cohen, U. A. Mirza, A. Hoffmann, B. T. Chait, R. G. Roeder, Y. Nakatani, S. K. Burley
Structural similarity between TAFs and the heterotetrameric core of the histone octamer
Nature, vol. 380, No.6572, 316-322 (1996)

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T. Kokubo, D-W. Gong, J. C. Wootton, M. Horikoshi, R. G. Roeder and Y. Nakatani
Molecular cloning of Drosophila TFIID subunits
Nature, vol.367, No.6462, 484-487 (1994)

T. Kokubo, S. Yamashita, M. Horikoshi, R. G. Roeder and Y. Nakatani
Interaction between the N-terminal domain of the 230 kDa subunit and the TATA box-binding subunit of TFIID negatively regulates TATA box-binding
Proc. Natl. Acad. Sci. USA, vol.91, No.9, 3520-3524 (1994)

T. Kokubo, D-W. Gong, S. Yamashita, R. Takada, R. G. Roeder, M. Horikoshi and Y. Nakatani
Molecular cloning, expression, and characterization of the Drosophila 85-Kilodalton TFIID subunit
Mol. Cell. Biol., vol.13, No.12, 7859-7863 (1993)

S. Yamashita, K. Hisatake, T. Kokubo, K. Doi, R. G. Roeder, M. Horikoshi and Y. Nakatani
Transcription factor TFIIB sites important for interaction with promoter-bound TFIID
Science, vol.261, 463-466 (1993)

T. Kokubo, D-W. Gong, S. Yamashita, M. Horikoshi, R. G. Roeder and Y. Nakatani
Drosophila 230-kDa TFIID subunit, a functional homolog of the human cell cycle gene product, negatively regulates DNA binding of the TATA box-binding subunit of TFIID
Genes & Dev., vol.7, No.6, 1033-1046 (1993)

T. Kokubo, D-W. Gong, R. G. Roeder, M. Horikoshi and Y. Nakatani
The Drosophila 110-kDa transcription factor TFIID subunit directly interacts with the N- terminal region of the 230-kDa subunit
Proc. Natl. Acad. Sci. USA, vol.90, No.13, 5896-5900 (1993)

T. Kokubo, R. Takada, S. Yamashita, D-W. Gong, R. G. Roeder, M. Horikoshi and Y. Nakatani
Identification of TFIID components required for transcriptional activation by upstream stimulatory factor
J. Biol. Chem., vol.268, No.23, 17554-17558 (1993)

R. Takada, Y. Nakatani, A. Hoffmann, T. Kokubo, S. Hasegawa, R. G. Roeder and M. Horikoshi
Identification of human TFIID components and direct interaction between a 250-kDa polypeptide and the TATA box-binding protein (TFIIDτ)
Proc. Natl. Acad. Sci. USA, vol.89, No.24, 11809-11813 (1992)

S. Yamashita, K. Wada, M. Horikoshi, D-W. Gong, T. Kokubo, K. Hisatake, N. Yokotani, S. Malik, R. G. Roeder and Y. Nakatani
Isolation and characterization of a cDNA encoding Drosophila transcription factor TFIIB
Proc. Natl. Acad. Sci. USA, vol.89, No.7, 2839-2843 (1992)

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Y. Yoshida, T. Miyata, M. Matsumoto, H. Shirotani-Ikejima, Y. Uchida, Y. Ohyama, T. Kokubo, Y. Fujimura
A novel quantitative hemolytic assay coupled with restriction fragment length polymorphisms analysis enabled early diagnosis of atypical hemolytic uremic syndrome and identified unique predisposing mutations in Japan
PLOS ONE, vol.10, No.5, e0124655 (2015)

Y. Yamamoto-Suzuki, Y. Sakurai, Y. Fujimura, M. Matsumoto, J. Hamako, T. Kokubo, H. Kitagawa, S. M. Kawsar, Y. Fujii, Y. Ozeki, F. Matsushita, T. Matsui
Identification and recombinant analysis of botrocetin-2, a snake venom cofactor for von Willebrand factor-induced platelet agglutination
Biochemistry, vol.51, No.26, 5329-5338 (2012)

C. Kano, R. Ouchida, T. Kokubo, J-Y. Wang
Rapid cell division contributes to efficient induction of A/T mutations during Ig gene hypermutation
Molecular Immunology, vol.48, No.15-16, 1993-1999 (2011)

Y. Kato, H. Kawasaki, Y. Ohyama, T. Morishita, H. Iwasaki, T. Kokubo, H. Hirano
Cell polarity in Saccharomyces cerevisiae depends on proper localization of the Bud9 landmark protein by the EKC/KEOPS complex
Genetics, vol.188, No.4, 871-882 (2011)

T. Sakai, H. Tochio, K. Inomata, Y. Sasaki, T. Tenno, T. Tanaka, T. Kokubo, H. Hiroaki, M. Shirakawa
Fluoroscopic assessment of protein leakage during Xenopus oocytes in-cell NMR experiment by co-injected EGFP
Anal Biochem., vol.371, No.2, 247-249 (2007)

T. Sakai, H. Tochio, T. Tenno, Y. Ito, T. Kokubo, H. Hiroaki, M. Shirakawa
In-cell NMR spectroscopy of proteins inside Xenopus laevis oocytes
J. Biomol. NMR, vol.36, No.3, 179-188 (2006)

T. Kokubo
, Y. Ambe-Ono, M. Nakamura, H. Ishida, T. Yamakawa, T. Kodama
Promotive effect of auxins on UDP-glucose: flavonol glucosyltransferase activity in Vitis sp. cell cultures
J.Biosci.Bioeng., vol.91, No.6, 564-569 (2001)

H. Takatsuka, Y. Sakurai, A. Yoshioka, T. Kokubo, Y. Usami, M. Suzuki, T. Matsui, K. Titani, H. Yagi, M. Matsumoto, Y. Fujimura
Molecular characterization of L-amino acid oxidase from Agkistrodon halys blomhoffii with special reference to platelet aggregation
Biochimica et Biophysica Acta, vol.1544, No.1-2, 267-277 (2001)

S. Miura, Y. Sakurai, H. Takatsuka, A. Yoshioka, M. Matsumoto, H. Yagi, T. Kokubo, Y. Ikeda, T. Matsui, K. Titani, Y. Fujimura
Total inhibition of high shear stress induced platelet aggregation by homodimeric von Willebrand factor A1-loop fragments
Br J Haematol, vol.105, No.4, 1092-1100 (1999)

M. Matsumoto, Y. Sakurai, T. Kokubo, H. Yagi, K. Makita, T. Matsui, K. Titani, Y. Fujimura, N. Narita
The cDNA cloning of human placental ecto-ATP diphosphohydrolases I and II
FEBS Lett, vol.453, No.3, 335-40 (1999)

Y. Sakurai, Y. Fujimura, T. Kokubo, K. Imamura, T. Kawasaki, M. Handa, M. Suzuki, T. Matsui, K. Titani, A. Yoshioka
The cDNA cloning and molecular characterization of a snake venom platelet glycoprotein Ib-binding protein, Mamushigin, from Agkistrodon halys blomhoffii venom
Thromb. Haemost., vol.79, No.6, 1199-1207 (1998)

T. Kokubo, M. Nakamura, T. Yamakawa, H. Noguchi and T. Kodama
Quercetin 3,7,4'-triglucoside formation from quercetin by Vitis hybrid cell cultures
Phytochemistry, vol.30, No.3, 829-831 (1991)

T. Kokubo, Y. Ambe, M. Nakamura, T. Yamakawa, H. Noguchi and T. Kodama
Quercetin 3-O-β-D-glucopyranoside and isorhamnetin 3-O-β-D-glucopyranoside formation from quercetin by cell cultures of Ipomoea batatas and Crocus sativum
Agric. Biol. Chem., vol.55, No.2, 613-614 (1991)

T. Kodama, H. Ishida, T. Kokubo, T. Yamakawa and H. Noguchi
Glucosylation of quercetin by a cell suspension culture of Vitis sp.
Agric. Biol. Chem., vol.54, No.12, 3283-3288 (1990)

INDEXに戻る

T. Kokubo
Essay: Mechanisms of Transcriptional Activation and Repression (p1210-1217)
Definitions: Activation Domain Shielding (p4-6), ATAC (p49-50), Chromatin Helicase DNA binding (CHD) (p402-404), INO80 (p1033-1035), ISWI (p1058-1060), Mammalian HDAC (p1173-1174), PIC Disassembly (p1715), Set3C (p1932-1933), TAND (p2121-2122), Tra1p (p2218-2219)
Encyclopedia of Systems Biology, W. Dubitzky, O. Wolkenhauer, K. H. Cho, H. Yokota (Eds.), Springer Science + Business Media LLC (2013)


T. Kokubo
Essay: Transcription in Eukaryote (p2239-2245)
Definitions: Cofactors (p436-437), Core Promoter Elements (p502-504), General Transcription Factors (p813-814), Mediator (p1217-1218), PIC Assembly Pathways (p1714-1715), RNA Polymerase I, II and III (p1862-1863), SAGA (p1890-1891), Type 3 Promoters (p2306-2307)

Encyclopedia of Systems Biology
, W. Dubitzky, O. Wolkenhauer, K. H. Cho, H. Yokota (Eds.), Springer Science + Business Media LLC (2013)

T. Kokubo
Essay: Transcription Initiation in Eukaryote (p2245-2251)
Definitions: Immobilized Template Assay (p989-990), Phosphodiester Bond Formation (p1702-1703), Stalk of RNAPII (p1982-1984), TAF Paralogs (p2120-2121), TFIIA-Like Factor (ALF) (p2163), TRF1 (p2299-2300), TRF2 (p2300-2301), TRF3 (p2301-2302)
Encyclopedia of Systems Biology, W. Dubitzky, O. Wolkenhauer, K. H. Cho, H. Yokota (Eds.), Springer Science + Business Media LLC (2013)

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古久保哲朗
V章 遺伝子発現系 5.1 転写
酵母のすべて ◎系統, 細胞から分子まで
大隅良典・下田 親 編(シュプリンガー・ジャパン)
p119-126 (2007)

奇 世媛、Tapas K Mal、Le Zheng、伊倉光彦、古久保哲朗
FRET(蛍光共鳴エネルギー移動)分光法 〜タンパク質間相互作用の解析〜
実験医学別冊:生命科学のための機器分析実験ハンドブック(羊土社)
p35-40 (2007)

古久保哲朗、奇 世媛、杉原文徳、白川昌宏
磁気共鳴法を利用した生細胞での遺伝子発現解析
テクノトレンド
バイオテクノロジージャーナル(羊土社)
p605-608, Vol.6, No.5 (2006)

古久保哲朗
第1章 転写開始反応の制御機構
バイオ研究マスターシリーズ
転写研究集中マスター(羊土社)
p42-51 (2005)

古久保哲朗
転写調節因子群と転写調節反応機構論
遺伝子発現〜ジーンセレクターから生命現象へ〜(中外医学社)
p87-105 (2001)

古久保哲朗
第5章 転写開始・伸長反応の制御機構
バイオサイエンスの新世紀 第1巻 遺伝子の構造と機能
日本生化学会 編集
p51-64 (2001)

古久保哲朗
基本転写因子TFIIDサブユニット(TAFs)の機能解析 
蛋白質核酸酵素増刊号
転写因子の機能〜転写制御複合体形成のダイナミクス〜
p1484-1493, vol.45, No.9 (2000)

中谷喜洋、古久保哲朗、伊倉光彦
TATAボックス構造をまねる転写因子
〜TAF230のユニークな転写阻害機構〜
実験医学 p2474-2476, Vol.16, No.19 (1998)

古久保哲朗
基本転写因子TFIIDの構造と機能
日本血栓止血学会誌 p257-267, Vol.7, No.4 (1996)

橘正芳、古久保哲朗
転写因子:基礎から臨床へ
Molecular Medicine p468-476, Vol.32, No. 5 (1995)

古久保哲朗
転写因子概説 
Molecular Medicine p478-486, Vol.32, No. 5 (1995)

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古久保哲朗
Vts1タンパク質のプリオン化により出芽酵母の環境適応能力が亢進する
News & Hot Paper Digest
実験医学
p1333-1334, vol.38, No.8 (2020)

古久保哲朗
出芽酵母のプロモーター上に”壊れやすい”ヌクレオソームは実在するのか?
News & Hot Paper Digest
実験医学
p1276-1278, vol.37, No.8 (2019)

古久保哲朗
運命決定に中心的に働く転写因子:パイオニア因子
出芽酵母における網羅的な同定と機能解析
News & Hot Paper Digest
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