発表論文

1.Cryo-EM structure of the conjugation H-pilus reveals the cyclic nature of the TrhA pilin.

Naito Ishimoto, Joshua L.C. Wong, Nanki Singh, Sally Shirran, Shan He, Chloe Seddon, Olivia Wright-Paramio, Carlos Balsalobre, Ravi R. Sonani, Abigail Clements, Edward H. Egelman, Gad Frankel, Konstantinos Beis

Proceedings of the National Academy of Sciences (PNAS), 122, 16, e2427228122, 2025

2.Cryo-EM structure and evolutionary history of the conjugation surface exclusion protein TraT

Chloe Seddon, Sophia David, Joshua LC Wong, Naito Ishimoto, Shan He, Jonathan Bradshaw, Wen Wen Low, Gad Frankel, Konstantinos Beis

Nature Communications, 16, 659, 2025

1.Structural insights into Influenza A virus RNA polymerase PB1 binding to nuclear import host factor RanBP5.

Tomomi Uchikubo-Kamo*, Naito Ishimoto*, Haruka Umezawa, Mikako Hirohama, Maasa Ono, Haruka Kawabata, Kenichi Kamata, Mio Ohki, Hisashi Yoshida, Jae-Hyun Park, Jeremy R.H. Tame, Atsushi Kawaguchi, Sam-Yong Park (*These authors contributed equally)

Biochemical and Biophysical Research Communications, 739, 150952, 2024

2.Structural basis for hepatitis B virus restriction by a viral receptor homologue.

Kaho Shionoya, Jae-Hyun Park, Toru Ekimoto, Junko S. Takeuchi, Junki Mifune, Takeshi Morita, Naito Ishimoto, Haruka Umezawa, Kenichiro Yamamoto, Chisa Kobayashi, Atsuto Kusunoki, Norimichi Nomura, So Iwata, Masamichi Muramatsu, Jeremy R.H. Tame, Mitsunori Ikeguchi, Sam-Yong Park, Koichi Watashi

Nature Communications, 15, 9241, 2024

3. Structural basis of hepatitis B virus receptor binding.

Jinta Asami, Jae-Hyun Park, Yayoi Nomura, Chisa Kobayashi, Junki Mifune, Naito Ishimoto, Tomoko Uemura, Kehong Liu, Yumi Sato, Zhikuan Zhang, Masamichi Muramatsu, Takaji Wakita, David Drew, So Iwata, Toshiyuki Shimizu, Koichi Watashi, Sam-Yong Park, Norimichi Nomura, Umeharu Ohto

Nature Structural and Molecular Biology, 31, 447-454, 2024

1. Structural basis for ligand recognition and signaling of hydroxy-carboxylic acid receptor 2.

Jae-Hyun Park, Kouki Kawakami, Naito Ishimoto, Tatsuya Ikuta, Mio Ohki, Toru Ekimoto, Mitsunori Ikeguchi, Dong-Sun Lee, Young-Ho Lee, Jeremy R. H. Tame, Asuka Inoue, Sam-Yong Park

Nature Communications, 14, 7150, 2023

2. Structural basis of CXC chemokine receptor 1 ligand binding and activation.

Naito Ishimoto, Jae-Hyun Park, Kouki Kawakami, Michiko Tajiri, Kenji Mizutani, Satoko Akashi, Jeremy R.H. Tame, Asuka Inoue, Sam-Yong Park

Nature Communications, 14, 4107, 2023

1. Structure of the human galanin receptor 2 bound to galanin and Gq reveals the basis of ligand specificity and how binding affects the G-protein interface.

Yunseok Heo*, Naito Ishimoto*, Ye-Eun Jeon, Ji-Hye Yun, Mio Ohki, Yuki Anraku, Mina Sasaki, Shunsuke Kita, Hideo Fukuhara, Tatsuya Ikuta, Koki Kawakami, Asuka Inoue, Katsumi Maenaka, Jeremy R.H. Tame, Weontae Lee, Sam-Yong Park (*These authors contributed equally)

PLoS Biology, 20, e3001714, 2022

2.Structural insights into the HBV receptor and bile acid transporter NTCP.

Jae-Hyun Park, Masashi Iwamoto, Ji-Hye Yun, Tomomi Uchikubo-Kamo, Donghwan Son, Zeyu Jin, Hisashi Yoshida, Mio Ohki, Naito Ishimoto, Kenji Mizutani, Mizuki Oshima, Masamichi Muramatsu, Takaji Wakita, Mikako Shirouzu, Kehong Liu, Tomoko Uemura, Norimichi Nomura, So Iwata, Koichi Watashi, Jeremy R.H. Tame, Tomohiro Nishizawa, Weontae Lee, Sam-Yong Park

Nature, 606, 1027-1031, 2022

3.Cryo-EM structure of the human somatostatin receptor 2 complex with its agonist somatostatin delineates the ligand-binding specificity.

Yunseok Heo, Eojin Yoon, Ye-Eun Jeon, Ji-Hye Yun, Naito Ishimoto, Hyeonuk Woo, Sam-Yong Park, Ji-Joon Song, Weontae Lee

eLife, 11, e76823, 2022

1.Pumping mechanism of NM-R3, a light-driven bacterial chloride importer in the rhodopsin family.

Ji-Hye Yun, Mio Ohki, Jae-Hyun Park, Naito Ishimoto, Ayana Sato-Tomita, Wonbin Lee, Zeyu Jin, Jeremy R.H. Tame, Naoya Shibayama, Sam-Yong Park, Weontae Lee

Science Advances, 6, eaay2042, 2020